IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission.

Prakash A, Fenner F, Shit B, Salminen TS, Monteith KM, Khan I, Vale PF

PLOS Pathogens. 2024; 10.1371/journal.ppat.1012308




Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila.

Vesala L, Basikhina Y, Tuomela T, Nurminen A, Siukola E, Vale PF, Salminen TS.

BMC Biology. 2024;22: 60. doi:10.1186/s12915-024-01858-5


Mitochondrial genome variation affects humoral and cell-mediated innate immune responses and infection outcomes.

Salminen TS, Vesala L, Basikhina Y, Kutzer M, Tuomela T, Lucas R, Monteith KM, Prakash A, Tietz, T, and Vale PF.

bioRxiv; 2024. p. 2024.03.28.587162. doi:10.1101/2024.03.28.587162


Genetic variation in trophic avoidance shows fruit flies are generally attracted to bacterial pathogens.

Monteith K, Thornhill P, Vale PF.

bioRxiv; 2024. p. 2024.05.09.593162. doi:10.1101/2024.05.09.593162


Mitochondrial background can explain variable costs of immune deployment.

Kutzer MAM, Cornish B, Jamieson M, Zawistowska O, Monteith KM, Vale PF.

Journal of Evolutionary Biology. 2024; voae027. doi:10.1093/jeb/voae027





Negative immune regulation contributes to disease tolerance in Drosophila.

Prakash A, Monteith KM, Vale PF.

bioRxiv; 2023. p. 2021.09.23.461574. doi:10.1101/2021.09.23.461574





Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection.

Prakash A, Monteith KM, Bonnet M, Vale PF.

Developmental & Comparative Immunology. 2023; 104756. doi:10.1016/j.dci.2023.104756



Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection.

Kutzer MAM, Gupta V, Neophytou K, Doublet V, Monteith KM, Vale PF.

Open Biology. 2023;13: 230025. doi:10.1098/rsob.230025






Ageing leads to reduced specificity of antimicrobial peptide responses in Drosophila melanogaster.

Shit B, Prakash A, Sarkar S, Vale PF, Khan I.

Proceedings of the Royal Society B: Biological Sciences. 2022;289: 20221642. doi:10.1098/rspb.2022.1642



Larval diet affects adult reproduction, but not survival, independent of the effect of injury and infection in Drosophila melanogaster.

Savola E, Vale P, Walling C.

Journal of Insect Physiology. 2022; 104428. doi:10.1016/j.jinsphys.2022.104428


Host genetics and pathogen species modulate infection-induced changes in social aggregation behaviour.

Romano V, Lussiana A, Monteith KM, MacIntosh AJJ, Vale PF.

Biology Letters. 2022;18: 20220233. doi:10.1098/rsbl.2022.0233




Mechanisms of damage prevention, signalling and repair impact disease tolerance.

Prakash A, Monteith KM, Vale PF.

Proceedings of the Royal Society B: Biological Sciences. 2022;289: 20220837. doi:10.1098/rspb.2022.0837



Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster.

Anderson L, Camus MF, Monteith KM, Salminen TS, Vale PF.

Heredity. 2022; 1–8. doi:10.1038/s41437-022-00554-w






Dissecting genetic and sex-specific sources of host heterogeneity in pathogen shedding and spread.

Siva-Jothy JA, Vale PF.

PLOS Pathogens. 2021;17: e1009196. doi:10.1371/journal.ppat.1009196



Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster).

Savola E, Montgomery C, Waldron FM, Monteith KM, Vale P, Walling C.

Evolution. 2021;75: 450–463. doi:10.1111/evo.14146




Carry on caring: infected females maintain their parental care despite high mortality.

Ratz T, Monteith KM, Vale PF, Smiseth PT.

Behavioral Ecology. 2021 [cited 21 Apr 2021]. doi:10.1093/beheco/arab028




Epidemiological dynamics of viral infection in a marine picoeukaryote.

Listmann L, Heath S, Vale PF, Schaum CE, Collins S.

bioRxiv; 2021. p. 2021.03.23.436719. doi:10.1101/2021.03.23.436719






Genotype and sex-based host variation in behaviour and susceptibility drives population disease dynamics.

White LA, Siva-Jothy JA, Craft ME, Vale PF.

Proceedings of the Royal Society B: Biological Sciences. 2020;287: 20201653. doi:10.1098/rspb.2020.1653


Drosophila as a Model System to Investigate the Effects of Mitochondrial Variation on Innate Immunity.

Salminen TS, Vale PF.

Frontiers in Immunology. 2020;11. doi:10.3389/fimmu.2020.00521



How are arbovirus vectors able to tolerate infection?

Oliveira JH, Bahia AC, Vale PF.

Developmental & Comparative Immunology. 2020;103: 103514. doi:10.1016/j.dci.2019.103514





Terminal investment strategies following infection are dependent on diet.

Hudson AL, Moatt JP, Vale PF.

Journal of Evolutionary Biology. 2020;33: 309–317. doi:10.1111/jeb.13566






Population-Level Disease Dynamics Reflect Individual Heterogeneities in Transmission.

Siva-Jothy JA, White LA, Craft ME, Vale PF.

bioRxiv; 2019. p. 735480. doi:10.1101/735480



Viral infection causes sex-specific changes in fruit fly social aggregation behaviour.

Siva-Jothy JA, Vale PF.

Biology Letters. 2019;15: 20190344. doi:10.1098/rsbl.2019.0344






The influence of parasites on insect behavior.

Vale PF, Siva-Jothy JA, Morrill A, Forbes MR.

in Insect Behavior: from mechanisms to ecological and evolutionary consequences. 2018;1.

Available at OUP or as a PDF.




Disease Tolerance: Linking Sickness Behaviours to Metabolism Helps Mitigate Malaria.

Vale PF.

Curr Biol. 2018;28: R606–R607. doi:10.1016/j.cub.2018.04.031




Oral Bacterial Infection and Shedding in Drosophila melanogaster.

Siva-Jothy JA, Prakash A, Vasanthakrishnan RB, Monteith KM, Vale PF.

J Vis Exp. 2018. doi:10.3791/57676




Navigating infection risk during oviposition and cannibalistic foraging in a holometabolous insect.

Siva-Jothy JA, Monteith KM, Vale PF.

Behav Ecol. 2018;29: 1426–1435. doi:10.1093/beheco/ary106




Infection avoidance behavior: Viral exposure reduces the motivation to forage in female Drosophila melanogaster.

Vale PF, Jardine MD.

Fly (Austin). 2017;11: 3–9. doi:10.1080/19336934.2016.1207029




Virus Resistance Is Not Costly in a Marine Alga Evolving under Multiple Environmental Stressors.

Heath SE, Knox K, Vale PF, Collins S.

Viruses. 2017;9. doi:10.3390/v9030039




The route of infection determines Wolbachia antibacterial protection in Drosophila.

Gupta V, Vasanthakrishnan RB, Siva-Jothy J, Monteith KM, Brown SP, Vale PF.

Proc Biol Sci. 2017;284. doi:10.1098/rspb.2017.0809




Nonlinear disease tolerance curves reveal distinct components of host responses to viral infection.

Gupta V, Vale PF.

R Soc Open Sci. 2017;4: 170342. doi:10.1098/rsos.170342



Costs and benefits of sublethal Drosophila C virus infection.

Gupta V, Stewart CO, Rund SSC, Monteith K, Vale PF.

J Evol Biol. 2017;30: 1325–1335. doi:10.1111/jeb.13096






Beyond killing: Can we find new ways to manage infection?

Vale PF, McNally L, Doeschl-Wilson A, King KC, Popat R, Domingo-Sananes MR, et al.

Evol Med Public Health. 2016;2016: 148–157. doi:10.1093/emph/eow012




Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus.

Vale PF, Lafforgue G, Gatchitch F, Gardan R, Moineau S, Gandon S.

Proc Biol Sci. 2015;282: 20151270. doi:10.1098/rspb.2015.1270



Sex-specific behavioural symptoms of viral gut infection and Wolbachia in Drosophila melanogaster.

Vale PF, Jardine MD.

J Insect Physiol. 2015;82: 28–32. doi:10.1016/j.jinsphys.2015.08.005




Host Genotype and Coinfection Modify the Relationship of within and between Host Transmission.

Susi H, Vale PF, Laine A-L.

Am Nat. 2015;186: 252–263. doi:10.1086/682069



Co-infection alters population dynamics of infectious disease.

Susi H, Barrès B, Vale PF, Laine A-L.

Nat Commun. 2015;6: 5975. doi:10.1038/ncomms6975



Microbiome engineering could select for more virulent pathogens.

McNally L, Vale PF, Brown SP.

bioRxiv; 2015. p. 027854. doi:10.1101/027854





Limiting damage during infection: lessons from infection tolerance for novel therapeutics.

Vale PF, Fenton A, Brown SP.

PLoS Biol. 2014;12: e1001769. doi:10.1371/journal.pbio.1001769



The evolution of resistance against good and bad infections.

Gandon S, Vale PF.

J Evol Biol. 2014;27: 303–312. doi:10.1111/jeb.12291



Host nutrition alters the variance in parasite transmission potential.

Vale PF, Choisy M, Little TJ.

Biol Lett. 2013;9: 20121145. doi:10.1098/rsbl.2012.1145




Killing them softly: managing pathogen polymorphism and virulence in spatially variable environments.

Vale PF.

Trends Parasitol. 2013;29: 417–422. doi:10.1016/




Elevated maternal temperature enhances offspring disease resistance in Daphnia magna.

Garbutt JS, Scholefield JA, Vale PF, Little TJ.

Functional Ecology. 2013; n/a-n/a. doi:10.1111/1365-2435.12197





The distribution of mutational fitness effects of phage φX174 on different hosts.

Vale PF, Choisy M, Froissart R, Sanjuán R, Gandon S.

Evolution. 2012;66: 3495–3507. doi:10.1111/j.1558-5646.2012.01691.x



Fecundity compensation and tolerance to a sterilizing pathogen in Daphnia.

Vale PF, Little TJ.

J Evol Biol. 2012;25: 1888–1896. doi:10.1111/j.1420-9101.2012.02579.x





Genetic influence on disease spread following arrival of infected carriers.

Fellous S, Duncan AB, Quillery E, Vale PF, Kaltz O.

Ecol Lett. 2012;15: 186–192. doi:10.1111/j.1461-0248.2011.01723.x




Epidemiological, evolutionary, and coevolutionary implications of context-dependent parasitism.

Vale PF, Wilson AJ, Best A, Boots M, Little TJ.

Am Nat. 2011;177: 510–521. doi:10.1086/659002




CRISPR-mediated phage resistance and the ghost of coevolution past.

Vale PF, Little TJ.

Proceedings of the Royal Society B: Biological Sciences. 2010;277: 2097–2103. doi:10.1098/rspb.2010.0055



Successfully resisting a pathogen is rarely costly in Daphnia magna.

Labbé P, Vale PF, Little TJ.

BMC Evol Biol. 2010;10: 355. doi:10.1186/1471-2148-10-355




Measuring parasite fitness under genetic and thermal variation.

Vale P, Little T.

Heredity. 2009;103: 102–109. doi:10.1038/hdy.2009.54



Infection outcomes under genetic and environmental variation in a host-parasite system: Implications for maintenance of polymorphism and the evolution of virulence.

Vale PF.

PhD, University of Edinburgh. 2009. Available:



2008 and earlier

The role of the environment in the evolutionary ecology of host parasite interactions.

Vale PF, Salvaudon L, Kaltz O, Fellous S.

Infect Genet Evol. 2008;8: 302–305. doi:10.1016/j.meegid.2008.01.011



Temperature-dependent costs of parasitism and maintenance of polymorphism under genotype-by-environment interactions.

Vale PF, Stjernman M, Little TJ.

J Evol Biol. 2008;21: 1418–1427. doi:10.1111/j.1420-9101.2008.01555.x



Parasite transgenerational effects on infection.

Little T, Birch * Jane, Vale P, Tseng M.

Evol Ecol Res. 2007;9: 459–469.




Comportamento social em bactérias. O papel dos cheaters na evolução da resistência a antibióticos.

Vale PF.

Universidade de Évora; 2004. Available: